St. Genis-Pouilly, France, 04 January 2023
Step Pharma, the world leader in CTPS1 inhibition for the targeted treatment of cancer, today announces the appointment of Dr Philip Beer as Chief Scientific Officer.
Philip is a board-certified haematologist with over 16 years of frontline healthcare experience as well as biopharmaceutical industry experience, particularly in translational medicine, drug development, and biomarker discovery.
He joined Step Pharma in June 2021 as Vice President, Head of Research & Translation Medicine and has led the Company’s research strategy and execution on the run up to Step Pharma’s lead asset, the targeted CTP synthase 1 (CTPS1) inhibitor STP938, entering the clinic in both the UK and US with compelling preclinical data in support.
Philip is being promoted to Chief Scientific Officer from Vice President, Head of Research & Translational Medicine at Step Pharma. In his new role, he will lead the Company’s research activities with a focus on further development of STP938, a first-in-class, highly selective, orally bioavailable inhibitor of CTPS1 currently being evaluated for safety and efficacy in T cell and B cell lymphomas.
Prior to joining Step Pharma, Philip held senior leadership roles in biotech and biopharma companies, overseeing oncology drug development and biomarker discovery programmes. He is a cofounder of Gabriel Precision Oncology, a clinical software company also focussed on improving outcomes for those living with cancer.
Andrew Parker, Chief Executive Officer of Step Pharma said:
“It has been a privilege working with Philip and advancing STP938 to the clinic with a strong pre-clinical data package built under his stewardship. As Chief Scientific Officer and with his extensive experience in leading oncology drug discovery and development programmes, he will continue his invaluable work to progress our pipeline of a novel class of oral drugs that specifically inhibit CTPS1, with the potential to yield highly selective, safe and effective treatments for both blood cancers and solid tumours..”
Dr Philip Beer, Chief Scientific Officer of Step Pharma, commented:
“I am honoured to be working with such a driven leadership team and thrilled to be promoted to the role of Chief Scientific Officer. Step Pharma is a highly innovative, research driven company with high quality science which has the potential to transform how we treat cancer. I remain committed to bringing Step Pharma’s targeted therapies to the clinic and to continue to develop life-saving treatments for patients.”
Philip is a Member of the Royal College of Physicians, UK, and a Fellow of the Royal College of Pathologists, UK. He holds a PhD in molecular cancer biology from the University of Cambridge, UK. Following this he conducted post-doctoral research studies at the BC Cancer Agency, Vancouver, Canada, and has more than 100 peer-reviewed publications. Philip is an Honorary Professor of Translational Medical at the Hull York Medical School, UK.
About Step Pharma
Step Pharma’s goal is to bring about a step change in how cancer is treated with targeted therapies that kill cancer cells and leave healthy cells unharmed. The Company is the world leader in CTPS1 inhibition, a new approach with the potential to yield highly selective, safe and effective cancer treatments for both blood cancers and solid tumours.
The Company’s lead product STP938 has received both IND and CTA clearance to proceed into first in human trials in the US and UK for the treatment of T cell and B cell lymphomas. Clinical trials in lymphoma commenced in September 2022. STP938 has the potential to be the backbone of a multitude of cancer therapies as well as a potent monotherapy for hard-to-treat blood cancers.
Step Pharma was founded in 2014 by Kurma Partners, the Imagine Institute and Sygnature Discovery, based on the scientific discoveries of Prof. Alain Fischer and Dr Sylvain Latour. Step Pharma is based in Saint-Genis-Pouilly, France, and is supported by a strong syndicate of investors led by Kurma Partners and including Bpifrance (Fonds Biothérapies Innovantes et Maladies Rares and InnoBio2 Fund), Pontifax, Hadean Ventures, Sunstone Life Science Ventures, Inserm Transfert Initiative, Idinvest, Sygnature Discovery and the Imagine Institute.
STP938 is a first-in-class, highly selective, orally bioavailable inhibitor of CTP synthase 1 (CTPS1), a key component of the pyrimidine synthesis pathway. CTPS1 inhibition inhibits the proliferation of neoplastic lymphoid cells and results in cell death. All cancers appear to be addicted to CTPS1 for DNA synthesis. STP938 entered clinical development in September 2022 for the treatment of T cell and B cell lymphoma.